|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
Serum and pancreatic tissues of APP/PS1 transgenic mice and wild-type mice were extracted and subjected to NMR analysis to evaluate the functional state of pancreas in the progress of AD.
|
31089202 |
2019 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
The lipidomic strategy proposed here involves lipoprotein profiling using NMR spectroscopy and multivariate data pre-processing and analysis tools on 94 plasma samples (belonging to 38 early-stage PD patients, 10 PD-related dementia patients, 23 persons with Alzheimer's dementia, and 23 healthy control subjects) to firstly differentiate PD patients (irrespective of the stage of the disease) from persons with Alzheimer's disease (AD) as well as from controls, and then to discriminate among PD patients according to disease severity.
|
30564825 |
2019 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
Progress in sample preparation, as well as solid-state NMR methods, recently enabled the determination of high-resolution 3D structures of fibrils such as the amyloid-β fibril, which is involved in Alzheimer's disease.
|
28916413 |
2017 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
Therefore, from a pomegranate extract (PE), previously reported by our group to have anti-AD effects in vivo, 21 constituents, which were primarily ellagitannins, were isolated and identified (by HPLC, NMR, and HRESIMS).
|
26559394 |
2016 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
(13)C-NMR spectroscopy revealed a shift in the Glx-2/Glx-4-ratio-where Glx represents a combined Glu/Gln-signal-towards Glx-2 in AD.
|
25742870 |
2015 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
In this study, 13-month-old triple transgenic mice (a mouse model of Alzheimer's disease (3xTg-AD)) were given intravenous infusion of [1-(13)C]glucose followed by an ex vivo (13)C NMR to determine the concentrations of (13)C-labeled isotopomers of Glu, Gln, aspartate (Asp), GABA, myo-inositol, and NAA.
|
24220168 |
2014 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
The present study investigates the fluxes of PC and PPP in a 20-month-old AβPP-PS1 mouse model of AD using 13C NMR spectroscopy together with an infusion of [2-13C]glucose.
|
24625793 |
2014 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study.
|
25099753 |
2014 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
GeneticVariation |
BEFREE |
We report a simulation study of coherent two-dimensional chiral signals of three NMR structures of Aβ protein fibrils associated with Alzheimer's Disease, two models for Aβ(8-40) peptide wild-type (WT) and one for the Iowa (D23N) Aβ(15-40) mutant.
|
21961527 |
2011 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
Biomarker |
BEFREE |
We show that the cyclin-dependent kinase 2/cyclin A3 kinase complex can generate the AT8 and AT180 AD-specific phospho-epitopes and use NMR spectroscopy to validate qualitatively and quantitatively the phospho content of our samples.
|
19074508 |
2009 |
|
LINC01672
|
Alzheimer's Disease
|
0.100 |
GeneticVariation |
BEFREE |
We describe a full structural model for amyloid fibrils formed by the 40-residue beta-amyloid peptide associated with Alzheimer's disease (Abeta(1-40)), based on numerous constraints from solid state NMR and electron microscopy.
|
19015532 |
2008 |