×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
PON1 is a disease modifier gene in amyotrophic lateral sclerosis : association of the Q192R polymorphism with bulbar onset and reduced survival.
30903418
2019
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
Biomarker
CTD_human
In addition, polymorphisms in paraoxonase 1 , an enzyme that detoxifies OPs, may increase individual vulnerability both to OP poisoning and to the risk of developing ALS .
28070599
2017
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
In addition, polymorphisms in paraoxonase 1 , an enzyme that detoxifies OPs, may increase individual vulnerability both to OP poisoning and to the risk of developing ALS .
28070599
2017
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.
25301263
2015
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
No links between PON1 polymorphisms or activity have been found in other neurodegenerative diseases such as multiple sclerosis and amyotrophic lateral sclerosis .
24225313
2014
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GermlineCausalMutation
ORPHANET
Genetics of amyotrophic lateral sclerosis: an update.
23941283
2013
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
Paraoxonase (PON ) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS ).
20381198
2011
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS ).
20582942
2010
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GermlineCausalMutation
ORPHANET
We now report that in genomic DNA from individuals with familial and sporadic ALS , we have identified at least 7 PON gene mutations that are predicted to alter PON function.
20582942
2010
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
Biomarker
BEFREE
Interaction between PON1 and population density in amyotrophic lateral sclerosis .
19104460
2009
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
In contrast to previous positive smaller studies, our genetic meta-analysis showed no significant association of amyotrophic lateral sclerosis (ALS ) with the PON locus.
19321847
2009
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
LHGDN
Interaction between PON1 and population density in amyotrophic lateral sclerosis.
19104460
2009
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
The possibility that organophosphorus (OP) compounds contribute to motor neuron disease (MND) is supported by association of paraoxonase 1 polymorphisms with amyotrophic lateral sclerosis (ALS ) and the occurrence of MND in OP compound-induced delayed neuropathy (OPIDN), in which neuropathy target esterase (NTE) is inhibited by organophosphorylation.
18313024
2008
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS .
18618303
2008
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
LHGDN
We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS .
18618303
2008
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
In addition, PON variants were shown to be associated with susceptibility to ALS in several North American and European populations.
18695162
2008
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
Biomarker
BEFREE
Contrary to expectations, PON1 protein, paraoxonase, diazoxonase, and arylesterase activities were not reduced in amyotrophic lateral sclerosis (ALS ).
18347314
2008
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
BEFREE
A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis .
17204329
2007
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
GeneticVariation
LHGDN
A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.
17204329
2007
×
Entrez Id:
5444
Gene Symbol:
PON1
PON1
Amyotrophic Lateral Sclerosis
0.700
Biomarker
HPO