|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
B cell activating factor (BAFF), a member of the tumor necrosis factor (TNF) family, plays a critical role in the pathogenesis and progression of rheumatoid arthritis (RA).
|
31240234 |
2019 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Therefore, in this review article, we studied BAFF and APRIL as important mediators in B-cell and discussed their role in rheumatoid arthritis.
|
30941763 |
2019 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
By targeting both ICOSL and BAFF, AMG 570 has the potential to achieve superior efficacy in treatment of autoimmune diseases such as SLE and rheumatoid arthritis.
|
30789152 |
2019 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Wild-type (WT) and BAFFtg mice were compared for B-Cell surface markers involved in MTX-related purinergic metabolism, adenosine production and regulatory B-cells (Bregs).We translated the study to macaques and patients with rheumatoid arthritis from the ABIRISK cohort to determine if there was an interaction between serum BAFF levels and MTX that prevented immuniation.
|
29936438 |
2018 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
TNFSF13B BAFF-var was significantly associated with RA (p = 0.015, OR = 1.21, 95% CI = 1.03-1.41) in the Spanish cohort.
|
29844438 |
2018 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic predisposition to several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.
|
30586461 |
2018 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study is to detect the pattern of genetic polymorphism of methylene tetrahydrofolate reductase (MTHFR C677 T and A1298 C), transforming growth factor-β1 (TGF-β1 T869 C) and lymphotoxin-α (LT-α A252G) in patients having rheumatoid arthritis and correlate these patterns to disease activity and serum levels of tumor necrosis factor-alpha (TNF-α), B-Cell Activating Factor (BAFF), and osteopontin.
|
27692391 |
2018 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of these cytokines detected in the sera of patients with systemic lupus erythematosus (SLE), IgA nephropathy, Sjögren's syndrome, and rheumatoid arthritis.
|
28215100 |
2017 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change, whereas the most important, BAFF receptor 3 (BR3), appears to be decreased before as well as after BCDT in all B cell subsets but not in plasmablasts, the most important subset, depleted by BCDT.
|
28834574 |
2017 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
B-cell activating factor (BAFF) has a role in the maturation and maintenance of B cells and is associated with rheumatoid arthritis (RA).
|
28383556 |
2017 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Serum levels of B cell-activating factor (BAFF) rise following rituximab (RTX) therapy in patients with rheumatoid arthritis (RA).
|
28800164 |
2017 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Our data suggest a critical role of miR-30a-3p in the regulation of BAFF expression, which could have a major impact in the regulation of the autoimmune responses occurring in RA and SSc.
|
25360821 |
2014 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the polymorphisms in the promoter region of the B lymphocyte stimulator (BLyS) gene as markers of response to rituximab (RTX) in rheumatoid arthritis (RA).
|
23001900 |
2013 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The BAFF-871C>T polymorphism seems to influence the response to RTX in RA patients after failure or intolerance to TNF blockers.
|
23264555 |
2013 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
B cell activating factor (BAFF) which plays a role in maturation and maintenance of B cells is also associated with autoimmune RA.
|
23684916 |
2013 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Disturbances in the expression of B cell-related activation and survival genes, particularly BAFF and TACI, occur from the onset of RA and precede changes in BAFF-R.
|
23772083 |
2013 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
BAFF and BAFF receptor (BAFF-R) are expressed in B and T cells of RA synovium.
|
21515993 |
2011 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
RASF, rheumatoid arthritis dermal fibroblasts (RADF) and osteoarthritis synovial fibroblasts (OASF) were analysed for the expression of B cell survival/proliferating factors BAFF and APRIL in resting conditions and upon stimulation with TLR2/TLR3/TLR4 ligands.
|
21798884 |
2011 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Transmembrane BAFF provided the first signal of RAG re-expression, since its down-regulation in RA FLS prevented RAG gene transcription in B cells.
|
19404965 |
2009 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Taken together, these findings identify BAFF as a valuable gene-silencing target potentially for the effective treatment of RA.
|
18820032 |
2008 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Baseline plasma BLyS protein levels, but not blood leukocyte BLyS mRNA levels, were elevated in patients with RA.
|
17967830 |
2008 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
In the present study, we examined the effect of dexamethasone (Dex) on constitutive and TNF-alpha- and IFN-gamma-induced BAFF expression in FLS-RA.
|
18316202 |
2008 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
The cells residing in the RA synovium might affect each other through BAFF.
|
17963166 |
2007 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression |
BEFREE |
Peripheral blood neutrophils cultured with 50% RA synovial fluid were study for membrane expression of BLyS.
|
17530706 |
2007 |
|
TNFSF13B
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Results from phase-II clinical trials with a BLyS antagonist in human SLE and RA have shown the antagonist to have biological and clinical activity along with a favorable safety profile.
|
17214581 |
2006 |