|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Increased risk of RA was associated with having any child compatible at HLA-B (OR 1.9; 1.2-3.1), DPB1 (OR 1.8; 1.2-2.6) or DQB1 (OR 1.8; 1.2-2.7).
|
30635658 |
2020 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Strong association was observed between SNP rs9277535 in HLA-DP and RA susceptibility (allele frequency distribution: OR = 1.409, 95%CI = 1.121-1.773, P = 0.004).
|
29476350 |
2018 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94).
|
30235330 |
2018 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
AlteredExpression |
BEFREE |
This meta-analysis demonstrates that high frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to RA, it may be a risk factor for occurrence of RA.
|
29425827 |
2018 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
We tested the association between having any child with alleles encoding amino acids (AAs) associated with RA including the 'shared epitope' (SE) and DERAA AA sequences at positions 70-74; AA valine, lysine and alanine at positions 11, 71 and 74 of HLA-DRB1; aspartic acid at position 9 of HLA-B and phenylalanine at position 9 of DPB1.
|
28391248 |
2017 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
A weighted genetic risk score (wGRS) was created using 45 RA non-human leucocyte antigen (HLA) susceptibility loci, imputed amino acids at HLA-DRB1 (11, 71 and 74), HLA-DPB1 (position 9) HLA-B (position 9) and gender.
|
24092415 |
2015 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.
|
23320107 |
2013 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
CTD_human |
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
|
22286218 |
2012 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
However, DPB1*02:01, DPB1*04:01 and DPB1*09:01 conferred RA risk/protection independently from DRB1.
|
22471586 |
2012 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Of these, four loci showed the strongest associations with RA (P<0.005): ZNF391, the olfactory receptor (OR) gene cluster, C6orf26-RDBP and HLA-DPB1-COL11A2.
|
21293383 |
2011 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DPB1 is an independent risk locus for ACPA-positive RA.
|
19116921 |
2009 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
CTD_human |
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.
|
17956852 |
2008 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
DPB1*0601 is reported to be a risk factor among RA patients, and glutamate at position 69 of the DPB1 molecule may be involved.
|
15703453 |
2005 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
The role of DPB1 remains hypothetical but may involve an influence of some alleles in relatively mild forms of RA.
|
11235775 |
2001 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DPB1*0401 may function in addition to HLA-DRB1*04, whereas HLA-DPB1*0201 and -DPB1*0601 may represent additional risk factors among (Q)R/KRAA-negative RA patients.
|
9442804 |
1997 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p < 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.
|
9157088 |
1996 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DPB1 alleles were not related to the clinical manifestations of patients with RA in Taiwan.
|
8596140 |
1995 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
The prevalence of the DPB1*0402 allele was higher in seropositive RA patients and DPB1*0201 was higher in seronegative RA patients.
|
8039286 |
1994 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
When HLA-DPB1 allelic frequencies were compared between seropositive RA patients and controls, a negative association for DPB1*0301 and DPB1*0401 was found in RA patients, although it failed to reach statistical significance after correction for the number of comparisons made.
|
9098423 |
1994 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA.
|
8182623 |
1994 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DPA1 and HLA-DPB1 in rheumatoid arthritis and its subsets.
|
8358964 |
1993 |
|
HLA-DPB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
No association was seen between RA and HLA-DPB1 type.
|
9098407 |
1993 |