|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
AAT heterozygous status in RA is strongly associated with positive ACPAs and may define a distinct subset of patients with increased disease severity.
|
28409899 |
2017 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Human AAT protein and gene therapies are able to ameliorate and delay arthritis development and reduce autoimmunity, indicating promising potential of these therapies as a new treatment strategy for RA.
|
21345239 |
2011 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
The results obtained in the present study indicate that a combination therapy using AAT and doxycycline holds promising potential as a new therapy for RA.
|
19866480 |
2010 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association of the alpha-1-antitrypsin PIZ allele with rheumatoid arthritis or with its extra articular complications.
|
1294360 |
1993 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
DNA variants of alpha-1-antitrypsin in rheumatoid arthritis with and without pulmonary complications.
|
1983194 |
1991 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
The genes coding for the protease inhibitors alpha 1-antitrypsin (A1AT) and alpha 1-antichymotrypsin (A1ACT) were analysed by Southern blot in patients with rheumatoid arthritis, psoriatic arthritis, psoriasis without arthritis, polymyalgia rheumatica and generalized osteoarthritis.
|
1974162 |
1990 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Alpha-1-antitrypsin (PI) and vitamin-D binding globulin (GC) phenotypes in rheumatoid arthritis: absence of an association.
|
2786461 |
1989 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Phenotype frequencies for variants of the chromosome 14 markers, alpha 1 antitrypsin (protease inhibitor--Pi), and immunoglobulin heavy chain gene allotypes (Gm and Am) were examined in affected and unaffected members of multicase rheumatoid arthritis (RA) families and compared with published population data.
|
3264137 |
1988 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
To test the pathogenetic role of the phenotype MZ of alpha 1-antitrypsin/alpha 1-protease inhibitor (PI) in acute anterior uveitis (AAU) and in different rheumatic diseases we examined 360 unrelated patients including 93 with AAU alone, 24 patients with AAU and ankylosing spondylitis (AS), 21 patients with AAU and Reiter's disease (RD), 26 patients with AAU, AS, and RD 54 patients with AS alone, 16 patients with RD alone, 115 patients with rheumatoid arthritis (RA) alone, and 11 patients with psoriatic arthritis (PA) alone.
|
3492856 |
1986 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Our findings suggest a possible role of alpha 1-antitrypsin in the pathogenesis of interstitial fibrosis in patients with RA.
|
3487321 |
1986 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.
|
3488034 |
1986 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Alpha-1-antitrypsin types and rheumatoid arthritis.
|
6610507 |
1984 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Reduced concentrations of alpha 1-antitrypsin in Z heterozygotes may be inadequate to inhibit the proteolytic enzymes released into the joints of adults with rheumatoid arthritis during phagocytosis of immune complexes.
|
6988116 |
1980 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
alpha 1-antitrypsin (alpha 1-A.T.) phenotypes were determined in 55 patients with rheumatoid arthritis (R.A.), 33 patients with R.A. and either obstructive airways disease or recurrent chest infections, 49 patients with fibrosing alveolitis (F.A.), 22 patients with R.A. and F.A., and 200 healthy controls.
|
72955 |
1977 |
|
SERPINA1
|
Rheumatoid Arthritis
|
0.100 |
Biomarker |
BEFREE |
Rheumatoid arthritis and alpha-1-antitrypsin.
|
58261 |
1976 |