|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
The interaction between TNF-α with TNFR1 triggers important signaling pathways inducing diverse cellular phenomena including inflammation, apoptosis, etc., and is involved in the pathogenesis and progression of numerous autoimmune diseases.
|
30414969 |
2019 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Thus, TNFR2 agonists or TNFR1-specific antagonists hold a potential promise for clinical application in treating patients with autoimmune diseases.
|
30631042 |
2019 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Tumor necrosis factor receptor 1 (TNFR1) is a central mediator of the inflammatory pathway and is associated with several autoimmune diseases such as rheumatoid arthritis.
|
31363069 |
2019 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
An ideal therapeutic strategy for autoimmune diseases would be to selectively block the sTNF/TNFR1 signal through the administration of sTNF inhibitors, or using TNFR1 antagonists while keeping the TNFR2 signaling pathway intact.
|
29725328 |
2018 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Collectively, we demonstrate the potential for anti-human TNFR1 therapies to effectively modulate immune responses in autoimmune disease.
|
30206422 |
2018 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Among these 52 genes, 7 were related to immunity, 3 were related to the tumor necrosis factor (TNF)-α receptor 1 (TNFR1) pathway (inhibitor of caspase-activated DNase (ICAD): FC = 1.8, P = 1.7E-7, FDR = 0.004; p21 protein-activated kinase 2 [PAK2]: FC = 1.66, P = 2.6E-5, FDR = 0.03; TNF-α-induced protein 8-like protein 1 [TNFAIP8L1]: P = 1.00E-05, FDR = 0.026), and 2 were related to Toll-like receptors (TLRs), especially TLRs 7 and 9, and were implicated in autoimmunity.
|
27175635 |
2016 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that TNFRSF1B T allele carriers show a better response to anti-TNF therapy, and individuals carrying TNFRSF1A A allele have no relationship with the response to anti-TNF therapy for autoimmune diseases.
|
26071216 |
2015 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
GeneticVariation |
BEFREE |
We describe 3 families (8 subjects) with the TNFRSF1A D12E substitution and TRAPS-related symptoms, in 4 cases associated with the autoimmune diseases multiple sclerosis and rheumatoid arthritis.
|
23322460 |
2013 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
CTD_human |
Thus, our results suggest that TNFR1 mediates SBS and dysregulation of clock genes in autoimmune diseases.
|
21074606 |
2011 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Collectively, these data demonstrated that targeting PLAD of TNFR1 provides protection from autoimmune diseases through the downregulation of Th17 and suggested a therapeutic potential of PLAD-modulation in TNF-involved inflammatory diseases.
|
21689905 |
2011 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
GeneticVariation |
BEFREE |
Although the ethnic diversity and clinical heterogeneity may propose the role of other genes in the pathogenesis of TRAPS, some low-penetrance TNFRSF1A variants contribute to atypical inflammatory responses in other autoimmune diseases.
|
16447098 |
2006 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
Biomarker |
BEFREE |
Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
|
15492850 |
2004 |
|
TNFRSF1A
|
Autoimmune Diseases
|
0.400 |
GeneticVariation |
BEFREE |
Moreover, the TNFRSF1A gene was examined in Japanese patients with autoimmune diseases, including SLE, rheumatoid arthritis (RA), mixed connective tissue disease (MCTD) and Behçet's disease, and in healthy Japanese controls.
|
15280569 |
2004 |