Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 GeneticVariation BEFREE Although several studies have investigated the association between C4, C4A, and C4B gene copy number variations (CNVs) and susceptibility to autoimmune diseases, the results remain inconsistency for those diseases. 28205620

2017

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 Biomarker BEFREE Genetic variants resulting in non-expression of complement C4A and C4B genes are common in healthy European populations and have shown association with a number of diseases, most notably the autoimmune disease, systemic lupus erythematosus. 21857912

2011

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 Biomarker CTD_human The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. 20452682

2010

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 GeneticVariation BEFREE The monomodular-short haplotype with a single C4B gene and the absence of C4A, which is in linkage-disequilibrium with HLA DRB1*0301 in Europeans and a strong risk factor for autoimmune diseases, has a frequency of 0.012 in AIA but 0.106 among healthy European Americans (p=6.6x10(-8)). 19135723

2009

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 GeneticVariation LHGDN Applications of these vigorously tested techniques may clarify the roles that human C4A and C4B gene-dosage variations play in infectious and autoimmune diseases. 12224044

2002

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 Biomarker BEFREE These patients probably carried all, or at least the class II and III regions, of the extended haplotype marked by B8/C4A*Q0/C4B1/BfS/DR3/DR52, which has been associated with several autoimmune diseases and is present in 11% of the healthy caucasoid population. 7923882

1994

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.360 Biomarker BEFREE It is probable that while interaction between certain HLA-DR3 and DR4-containing supratypes is important in conferring susceptibility to Type 1 diabetes, other manifestations of autoimmunity are associated with supratypes containing C4AQ0, and in particular the diabetogenic supratype HLA-B8-C4AQ0-C4B1-BfS-DR3. 6332753

1984