|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Since cancer stem cells (CSCs) are radioresistant and metastasis-initiating cells, we examined TGLI1 for its involvement in breast CSCs and found TGLI1 to transcriptionally activate stemness genes CD44, Nanog, Sox2, and OCT4 leading to CSC renewal, and TGLI1 outcompetes with GLI1 for binding to target promoters.
|
31462709 |
2020 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Hypoxia also enhanced the expression of cancer stem cell (CSC) transcription factors (NANOG, Oct4, SOX2), CD133 and EMT markers (N-cadherin, Vimentin), thereby supporting invasion.
|
31634481 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
D7-6 G cells had increased expression of cancer stem cells markers Oct4, Sox2, and Nanog; aldehyde dehydrogenase expression and activity; proportion of CD44<sup>+</sup>CD24<sup>-</sup>cells.
|
30579251 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The results demonstrated Wnt/β-catenin signaling was activated and was able to form mammospheres with increased cancer stem cell markers (ALDH1, NANOG, and OCT4) in endocrine-resistant cells.
|
31693936 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
POU5F1 (OCT4) is implicated in cancer stem cell self-renewal.
|
31012189 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, the nuclear localization of OCT3/4 protein in primordial follicle-enclosed oocytes suggests a possible increased activity of ovarian stem cells in response to chemotherapy and/or extragonadal cancer.
|
30857552 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
|
31786016 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
We observed that miR-147 was downregulated in several colon cancer cell lines, and overexpressed miR-147 decreased the expression of cancer stem cell (CSC) markers OCT4, SOX2, and NANOG in the colon cancer cell lines HCT116 and SW480.
|
29426374 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In conclusion, our study suggested that bFGF/FGFR signalling plays an important role in maintaining lung cancer stem cell characteristics and regulating expression of cancer stem cell marker of OCT-4.
|
31282010 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
After the treatment period, the tumor tissues were weighed and harvested for mRNA and protein isolation. qPCR and Western blotting were used to evaluate the expression of cancer stemness markers (epithelial cell adhesion molecule [EpCAM], cluster of differentiation [CD13], CD90, aldehyde dehydrogenase 1 [ALDH1], CD44, and CD45), totipotency factors (sex determining region Y-box 2 [Sox2], Nanog, and octamer-binding transcription factor 4 [Oct4]), and genes involved in the Notch, Wnt/<i>β</i>-catenin, Hedgehog, and Hippo signaling pathways.
|
31341493 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Egr1 exerts a promoting effect on cancer metastasis in Oct4-overexpressing lung cancer.
|
31399076 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
CLIC4 expression is lowest in MKN45 cells，which have the highest tumorigenic potential and express the highest levels of cancer stem cell markers CD44 and OCT4, compared to N87 and AGS cells.
|
31560739 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
<b>Objective:</b> Using the gastric cancer cell line SGC7901, we constructed a cell line that overexpressed octamer-binding protein 4 (Oct4) and SRY-box 2 (Sox2) to explore the stem cell oncological and biological characteristics of these cells and to elucidate the mechanisms of Oct4 and Sox2 in cancer.
|
31417271 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4.
|
31040921 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct4 expression cells have self-renewal and differentiation abilities like those of cancer stem cells.
|
31191684 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4).
|
31757938 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Furthermore, during ethanol-induced cellular transformation, cells gained the phenotypes of cancer stem cells (CSCs) by expressing pluripotency maintaining factors (Oct4, Sox2, cMyc and KLF4) and stem cell markers (CD24, CD44 and CD133).
|
29761897 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The high expression of cancer stem cell transcription factors (Oct4, Sox2 and Nanog) is a valuable prognostic factor, suggesting a higher risk of tumor recurrence and metastasis.
|
29907293 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Oct4 promotes cancer cell proliferation and migration and leads to poor prognosis associated with the survivin/STAT3 pathway in hepatocellular carcinoma.
|
29901157 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis.
|
29223130 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, TGFβ1 was able to enhance the mRNA expression of Oct4, Nanog and Sox2 and drastically increased anchorage-independent colony formation in TGFβ1-sensitive NSCLC cells, suggesting the acquisition of cancer stem-like properties.
|
29995950 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The activated p-AKT enhances SOX2 and OCT4 activity and thereby maintains cancer cell stemness.
|
29477378 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
S100A16 up-regulates Oct4 and Nanog expression in cancer stem-like cells of Yumoto human cervical carcinoma cells.
|
29928366 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
MiRNA-145, SOX2, and OCT4 were expressed at similar levels in two cancer sites of a given DPEEOC or metastatic DEEOC sample.
|
29569698 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
<i>NANOG</i> and <i>OCT3/4</i> mRNA expression levels were significantly downregulated while that of <i>SOX2</i> was upregulated in cancer compared to noncancer tissues.
|
29849920 |
2018 |