Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE Supplementation of p-CA downregulated Grp78 and activated UPR mediated apoptosis both in in vitro and in vivo models of colon cancer. 29879413

2018
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE Furthermore, high levels of GRP78 expression have been shown to increase the risk of malignancy and metastasis in prostate and colon cancer. 28551635

2017
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker BEFREE Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigated the dynamic relationship between the 78-kDa glucose-regulatory protein (GRP78) and the phosphoinositide 3-kinase (PI3K)/Akt pathway. 26225471

2015
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker BEFREE GRP78 mediates the therapeutic efficacy of curcumin on colon cancer. 25277658

2015
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker BEFREE However, the role of GRP78 in the metastasis of colon cancer is unclear. 25431258

2015
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE The level of GRP78 expression may determine the therapeutic efficacy of 17-DMAG against colon cancer cells. 25618598

2015
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE Here we report that forced GRP78 expression promotes colon cancer cell migration and invasion through upregulating MMP-2, MMP-9 and especially uPA production. 24314144

2014
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE We first checked the expression of GRP78 in human normal and colon cancer tissues and two colon cancer cell lines. 23759331

2013
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker BEFREE This study demonstrates the significance of cell surface GRP78 in colon cancer, which may be used as a marker for reduced tumorigenicity. 22945507

2012
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. 22529978

2012
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE DHA treatment induced apoptosis in three colon cancer cell lines (HT-29, HCT116 and SW480), and inhibited their total and surface GRP78 expression. 22898250

2012
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE One of the identified proteins, GRP78, exhibited a marked up-regulation in colon cancer tissue. 16182273

2006
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression BEFREE These observations prompted us to examine whether 6-AN pre-treatment can result in the over-expression of GRP78 in human colon cancer cell lines and, if so, whether this increase is associated with sensitization to DNA cross-linking agents outlined above. 10198218

1999