Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression BEFREE Moreover, leptin induced up-regulation of SIRT1 in human colon cancer (HCT-116) cells. 29427626

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker BEFREE Here in, we investigated the anti-tumor effect of EA in the presence of leptin to reflect on therapeutic use of EA in obesity-linked colon cancer. 27460082

2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker BEFREE The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. 23558862

2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker BEFREE Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer. 22193626

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression BEFREE Our results demonstrated that lycopene significantly inhibited leptin-mediated cell invasion and MMP-7 expression in human colon cancer HT-29 cells. 21923160

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation BEFREE Adipose tissue secretes factors linked to colon cancer risk including leptin. 19221001

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression BEFREE Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF). 19492417

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker BEFREE These data support an association between LEP and colon cancer. 18059035

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker CTD_human Leptin promotes the growth of Colon 38 cancer cells and interferes with the cytotoxic effect of fluorouracil in vitro. 17354198

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression BEFREE Obesity, a risk factor for colon cancer, is associated with elevated serum levels of leptin, a protein produced by adipocytes. 17170030

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression BEFREE The secretion of adiponectin and macrophage colony-stimulating factor, as well as leptin and migration inhibitory factor, was significantly upregulated in CD compared with CC and diverticulitis or CC only, respectively. 16775490

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker BEFREE Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice. 15857934

2005