POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
bFGF decreased NSCLC sensitivity to cisplatin in vitro, while it enhanced colony formation ability and increased OCT-4 expression of A549 cells, which might account for its involved mechanisms of cisplatin resistance.
|
30589033 |
2018 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker |
BEFREE |
NDRG1 promoted stem-like properties of LTICs in NSCLC including iPSC (induced pluripotent stem cell) factors (OCT4, SOX2, KLF4, and C-MYC), the spheres-forming ability and the tumorigenicity of NSCLC.
|
28456659 |
2017 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
We therefore identified the EMT phenotype-based subsets of CTCs and determined the OCT4 expression status of CTCs in NSCLC patients, to explore their possible clinical relevance.
|
28374320 |
2017 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker |
BEFREE |
We further demonstrated that inactivation of p38 is a potential mechanism contributing to acquisition and maintenance of cancer stem cell properties in non-small cell lung cancer (NSCLC) cells. p38, in particular the p38γ and p38δ isoforms, suppresses the cancer stem cell properties and tumor initiating ability of NSCLC cells by promoting the ubiquitylation and degradation of stemness proteins such as SOX2, Oct4, Nanog, Klf4 and c-Myc, through MK2-mediated phosphorylation of Hsp27 that is an essential component of the proteasomal degradation machinery.
|
28460458 |
2017 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker |
BEFREE |
Our findings indicate that targeting OCT4 could improve cisplatin effect in NSCLC, confirming their role in modulating cisplatin sensitivity.
|
27832473 |
2017 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
DSF/Cu (0.5/1 μmol/l) significantly inhibited the expression of stem cell transcription factors (Sox2, Oct-4 and Nanog) and reduced the capacities of NSCLC stem cells for self-renewal, proliferation and invasion in vitro.
|
27542268 |
2016 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker |
BEFREE |
Knockdown of OCT4 in NSCLC cells could decrease cell proliferation, and potentiate apoptosis induced by gefitinib, suggesting OCT4 may contribute to gefitinib resistance in NSCLC.
|
27816965 |
2016 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker |
BEFREE |
The aim of this study was to elucidate the role of Oct4 in the resistance to gefitinib in NSCLC cells with an activating epidermal growth factor receptor (EGFR) mutation.
|
26996130 |
2016 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
The binding of Oct4 to YAP1 could be detected in cell lines as well as tumor tissues; the interaction was elevated in NSCLC samples compared to normal tissue as seen by proximity ligation assays.
|
25754111 |
2015 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
The objective of the current study was to examine the association between Oct4 and KPNA2 expression levels with regard to both the clinicopathological characteristics and prognoses of patients with non-small-cell lung cancer (NSCLC).
|
24070213 |
2013 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
We measured Oct-4 expression in 113 NSCLC tissue samples and three cell lines by immunohistochemical staining and RT-PCR.
|
22300949 |
2012 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention.
|
19126554 |
2009 |
POU5F1P4
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer.
|
18612434 |
2008 |