Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE COPD and Cardiovascular Disease. 30527374

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE A total of 52 patients with OSA requiring CPAP > 15 cm H<sub>2</sub> O (71% male, age: 58 (15) years, BMI: 42.6 (10.1) kg/m<sup>2</sup> , apnoea-hypopnoea index (AHI): 51.1 (30.4)/h) were studied; 62% had respiratory co-morbidities affecting nocturnal breathing including obesity hypoventilation syndrome and COPD; 25% had neuromuscular conditions; and 17% had cardiovascular disease. 31407464

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. 30519014

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE At the same time, increasing recognition of the considerable cardiovascular disease burden and its suboptimal treatment in patients with COPD has also contributed to continued enthusiasm for statin use in COPD. 30418244

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE Pooled prevalence for the most significant NCDs was a follows; cancer 8% (95% CI 6-10%), cardiovascular disease 38% (95% CI 33-42%), hypertension 39% (95% CI 32-47%), diabetes 14% (95% CI 12-16%), COPD prevalence estimates ranged from 4% to 18%.Heterogeneity across studies was high. 30590404

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE A substantial prevalence of cardiovascular disease is known for COPD, but detection of its presence, relationship to functional findings and contribution to symptoms remains challenging. 31571852

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. 30617161

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Cardiovascular disease is often associated with COPD. 30349236

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Current smoking (RR 0.89, 95% CI 0.75-1.06; <i>P</i>=0.178), American Society of Anesthesiologists grade >2 (RR 2.63, 95% CI 0.84-8.27; <i>P</i>=0.098), increased age (WMD 1.43 years, 95% CI -1.15 to 4.02; <i>P</i>=0.278), COPD (RR 1.21, 95% CI 0.68-2.17; <i>P</i>=0.521), cardiovascular disease (RR 1.63, 95% CI 0.40-6.70; <i>P</i>=0.495), rheumatoid arthritis (RR 1.76, 95% CI 0.53-5.90; <i>P</i>=0.359), and osteoporosis (RR 1.91, 95% CI 0.79-4.63; <i>P</i>=0.152) were not risk factors for postoperative SSI. 30464489

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE Comorbidities included the following: obesity (n = 95, 78.5%), hypertension (n = 72, 59.5%), cardiovascular disease (n = 42, 34.7%), diabetes (n = 40, 33.1%), COPD (n = 34, 28.1%), malignancy (n = 30, 24.8%), active smoker (n = 28, 23.1%), immunosuppression (n = 10, 8.3%), chronic corticosteroid use (n = 6, 5.0%), advanced age (n = 6, 5.0%), hypoalbuminemia (n = 3, 2.5%), and renal insufficiency (n = 1, 0.8%). 29063307

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Patients with COPD are frequently diagnosed with cardiovascular disease. 30170800

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE BH<sub>4</sub> may represent a potential novel therapy to improve endothelial function and reduce cardiovascular disease risk in patients with COPD. 29705218

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Associations between COPD and individual CVDs were heterogeneous, with the highest relative risks observed for heart failure and diseases of the arterial circulation (in excess of 2.5 for those aged 64-75 years). 29438071

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE The association between baseline NT-proBNP and incident COPD exacerbations within one year of follow-up was tested using zero-inflated Poisson regression models adjusted for age, gender, race, body mass index, current smoking status, smoking history, FEV<sub>1</sub> percent predicted, COPD Assessment Test score, exacerbation history, total lung capacity on chest CT and cardiovascular disease (any of coronary artery disease, myocardial infarction or congestive heart failure). 29957287

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Increased mortality among adult asthmatics was largely explained by the development of COPD, malignant respiratory tract neoplasms, and cardiovascular diseases. 29461632

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE When the HIV-positive group was stratified based on the duration of HIV infection, most of the co-morbidities were significantly more frequent than in control patients, except for hypertension and cardiovascular disease, while COPD was more prevalent in the control group. 29678160

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE With increasing use of nongated CT scans in clinical practice, this study hypothesized that the visual Weston CAC score would perform as well as the Agatston score in predicting prevalent and incident coronary artery disease (CAD) and CVD in COPD. 29890123

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Cardiovascular diseases play a major role in morbidity and mortality in the earlier stages of COPD. 29501244

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE All all-cause, COPD and cardiovascular disease mortality was analyzed among men and women in relation to AL<sub>GOLD</sub> and AL<sub>LLN</sub>, adjusted for age and smoking. 30366582

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE We performed a secondary cohort analysis of the SUMMIT (Study to Understand Mortality and Morbidity) trial, a convenience sample of current/former smokers with moderate COPD from 1,368 centers in 43 countries.All had CVD or increased CVD risk. 29442524

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Cardiovascular disease is a frequent comorbidity in patients with COPD. 29355547

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Our paper aims to summarize existing data regarding subclinical CVD in patients with COPD with a view to identifying screening strategies in these patients. 27539486

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. 27884766

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Selective beta-blockers can be cautiously prescribed for patients with COPD and cardiovascular disease (CVD), however, nonselective beta-blockers should not be prescribed for patients with COPD. 29066880

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE We identified 50 eligible studies.We found that waterpipe tobacco smoking was significantly associated with: respiratory diseases [COPD; odds ratio (OR) = 3.18, 95% confidence interval CI = 1.25, 8.08; bronchitis OR = 2.37, 95% CI = 1.49, 3.77; passive waterpipe smoking and wheeze OR) = 1.97, 95% CI = 1.28, 3.04]; oral cancer OR = 4.17, 95% CI = 2.53, 6.89; lung cancer OR = 2.12, 95% CI = 1.32, 3.42; low birthweight (OR = 2.39, 95% CI = 1.32, 4.32); metabolic syndrome (OR 1.63-1.95, 95% CI = 1.25, 2.45); cardiovascular disease (OR = 1.67, 95% CI = 1.25, 2.24); and mental health (OR 1.30-2.4, 95% CI = 1.20, 2.80). 27075769

2017