Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Statins, also known as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, and antidepressant drugs are frequently used in combination due to the high and growing incidence of cardiovascular diseases and psychiatric disorders worldwide. 31587356

2020

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are a well-known class of drug with beneficial therapeutic effects in cardiovascular disease and lipid disorders and have potential use against cancer. 30203471

2019

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 GeneticVariation BEFREE Statins inhibit the action of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), which is important in the synthesis of cholesterol and essential isoprenoid intermediates, thereby lowering circulating low-density lipoprotein cholesterol (LDL), a major risk factor for cardiovascular disease (CVD). 29935271

2018

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Lovastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor that is clinically used for the prevention of cardiovascular diseases. 29207042

2018

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are medications that have been used for decades to lower cholesterol and to prevent or treat cardiovascular diseases. 29238220

2017

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes. 27959767

2016

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. 25444240

2015

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE Simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, is invariably used to treat cardiovascular diseases. 26539474

2015

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 GeneticVariation BEFREE Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins) are prescribed to lower serum cholesterol levels and reduce the risk of CVD. 22688219

2013

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 Biomarker BEFREE The statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been proven to be effective in lowering cholesterol and as anti-lipid agents against cardiovascular disease. 22134829

2012

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 GeneticVariation BEFREE We analysed the sequence of the HMG-CoA reductase gene in DNA extracted from blood samples of 16 patients with cardiovascular disorders. 19187128

2009

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.200 GeneticVariation BEFREE Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. 18261733

2008