On the whole, these findings suggest that EZH2, H3K27me3 and DNMT3A mediate the epigenetic regulation of the negative stimulatory molecules, Tim‑3 and galectin‑9 in cervical cancer which is associated with HPV18 infection.
Conclusion: These results demonstrated that lncRNA-EBIC was an oncogenic lncRNA, which could promote tumor cell invasion in CC by binding to EZH2 and inhibiting E-cadherin expression.
We aim to clarify whether specificity protein 1 (Sp1) and enhancer of zeste homolog 2 (EZH2) are involved in the regulation of LMX1A in cervical cancer.
High EZH2 expression may be associated with tumor cell proliferation and invasion in cervical cancer, and that EZH2 may be one of the candidates for new molecular therapeutic targets for the treatment of cervical cancer.