|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
CRC spheroid cells showed increased CSC characteristics over their monolayer cells with increased expression of CD44 and over expression of Oct3/4, Sox2 and Nanog.
|
31360304 |
2019 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
The aim of this study was to examine the relationship between Oct4 expression and liver metastasis of colorectal cancer (CRC) in clinical samples and investigate the role and abilities of Oct4-positive CRC cells.
|
31191684 |
2019 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
Therefore, targeting the PrP<sup>C</sup> -Oct4 axis may prove instrumental in colorectal cancer therapy.
|
30091203 |
2018 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
Downregulation of POU5F1P4 decreased the sensitivity of colorectal cancer cells to cetuximab.
|
29136952 |
2018 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
New data consolidate the role of core pluripotency transcription factors OCT4, SOX2 and NANOG as adverse prognostic factors in colorectal cancer. mRNA-binding proteins LIN28 and Musashi, that are associated with stemness, and epigenetic modifiers such as de-acetylase SIRT1 may also have prognostic value in colorectal cancer.
|
29944017 |
2018 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
Finally, we analyzed the expression and clinical significance of epithelial-to-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) and cancer stem cell (CSC) markers (Nanog, Oct-4, and Sox-2) in CRC tissues.
|
29081665 |
2017 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
MACC1 Induces Tumor Progression in Transgenic Mice and Colorectal Cancer Patients via Increased Pluripotency Markers Nanog and Oct4.
|
26758557 |
2016 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
Due to existence of transcriptional linkage between DPPA2/Nanog and OCT4 in mouse ESCs, our results suggest that a pluripotency transcriptional network consisting of SALL4/OCT4/DPPA2/Nanog, as similar as ESCs, is activated in CRC which not only play essential roles in maintenance of stemness state and self-renewal characteristics of tumor cells, but also in progression of CRC cells through advanced stages leading to increase depth of tumor cell invasion.
|
25497006 |
2015 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
Conversely, the mRNA expression levels of YAP, TAZ, TEAD, and OCT4 showed a decreasing tendency from CRC to adjacent nontumorous tissues (P < 0.001).
|
24976283 |
2015 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
We found that OCT4 knockdown inhibited colorectal cancer cell motility and invasion (in vitro) and decreased hepatic colonization (in vivo).
|
23076549 |
2013 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, an independent public expression profiling data showed signature for the four iPS genes could successfully be used to predict the survival of CRC patients with Dukes stages B and C. Immunofluorescent staining of fresh CRC tissues from patients showed that strong co-expressions of Oct4 and Nanog proteins or Sox2 and Lin28 were present in some CRC cells.
|
23307247 |
2013 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
To examine OCT4 expression in colorectal cancer (CRC) tissues, and to assess the efficacy of OCT4 as a potential biomarker for CRC, in this study, we investigated its expression in CRC tissues, evaluated its relationship to various clinicopathological parameters and defined the isoform of OCT4 that was found to be expressed in CRC cases.
|
21480394 |
2012 |
|
POU5F1P4
|
Colorectal Carcinoma
|
0.100 |
Biomarker |
BEFREE |
Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells.
|
22037460 |
2011 |