Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer in Hispanics. 27207650

2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Therapeutic RGD Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. 23149858

2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression BEFREE Herein we show that MMP-2 is up-regulated in resected colorectal tumors and degrades β1 integrins with the release of fragments containing the β1 I-domain. 22898815

2012
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247

2011
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression BEFREE The high expressions of MMP2 and MMP9 were closely associated with invasion and migration of colorectal tumors and cell lines. 20191032

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression LHGDN Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer. 18425389

2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker CTD_human Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. 18507500

2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker LHGDN MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. 18506186

2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 GeneticVariation LHGDN Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese. 17546628

2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression LHGDN Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases. 18214299

2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker BEFREE Matrix metalloproteinase (MMP)-7 (matrilysin-1) plays significant roles in the growth, invasion, and metastasis of colorectal tumors, while (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol with chemopreventive properties, has been shown to be an inhibitor of MMP-2 and MMP-9. 15860507

2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 GeneticVariation LHGDN A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer. 15485653

2004
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker LHGDN Laminin-5 gamma 2 chain and matrix metalloproteinase-2 may trigger colorectal carcinoma invasiveness through formation of budding tumor cells. 14666611

2003
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker LHGDN Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients. 14520690

2003
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Biomarker BEFREE Balance between activation and inhibition of matrix metalloproteinase-2 (MMP-2) is altered in colorectal tumors compared to normal colonic epithelium. 12184536

2002
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression BEFREE We evaluated levels and activity of gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as stromelysin-1 (MMP-3) expression in 101 sporadic colorectal tumors in consideration of the microsatellite instability (MSI) status of the groups. 12097300

2002
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 AlteredExpression BEFREE Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. 8913260

1996