Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 GeneticVariation BEFREE Overall, these data complement earlier studies in which CVID-associated STAT3 mutations are predicted to enhance transcriptional activity, suggesting that such patients may respond favourably to IL-6 receptor antagonists (e.g. tocilizumab). 29180260

2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 GeneticVariation BEFREE In conclusion, our results indicated association between CVID and cytokine gene polymorphisms -308G/A TNF and -174G/C IL6. 27288995

2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 Biomarker BEFREE Furthermore, Pneumovax-23-induced secretion of IL-6 and TNF-alpha was significantly less in patients with CVID as compared with controls. 20177958

2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 GeneticVariation BEFREE Vitamin D receptor and IL-6 alleles were associated with immunophenotypic abnormalities characteristic of more severe disease; and tumour necrosis factor and IL-10 alleles conferred susceptibility to the granulomatous form of CVID in an interacting fashion. 11196660

1999
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 AlteredExpression BEFREE Increased IL-6 gene expression and production in patients with common variable immunodeficiency. 8485909

1993
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.060 Biomarker BEFREE Elevated serum interleukin-6 associated with a failure in B cell differentiation in common variable immunodeficiency. 2229813

1990