Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6464
Gene Symbol: SHC1
SHC1
CUI: C0011847
Disease: Diabetes
Diabetes 		0.020 GeneticVariation BEFREE As p66(Shc) modulates the production of cellular ROS, it represents a proximal node through which high glucose exerts its deleterious effects on different cell types; indeed, several studies tested the hypothesis that deletion of the p66(Shc) gene may confer protection against diabetes-related cardiovascular complications. 19590843

2009
Entrez Id: 6464
Gene Symbol: SHC1
SHC1
CUI: C0011847
Disease: Diabetes
Diabetes 		0.020 AlteredExpression BEFREE In conclusion, diabetes induces p66(shc) gene expression in circulating PBM; this up-regulation in expression is significantly associated with markers of oxidative stress. p66(shc) gene expression in PBM may represent a useful tool to investigate the oxidative stress involved in the pathogenesis of long-term diabetic complications. 15562031

2005