|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
The Montecarlo Exact Fisher Test demonstrated marked differences in all three Loci, DQA1, DQB1, DRB1 (p<0.0001) between AP versus both AITD and controls, as well as between AP type II (Addison's disease as major endocrine component) and AP type III (T1D + AITD).
|
31675055 |
2019 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
The heterozygous DQ2/8 (DQA1*05:01-DQB1*02:01/DQA1*03:01-DQB1*03:02) genotype confers the highest risk in type 1 diabetes (T1D), whereas the DQ6/8 (DQA1*02:01-DQB1*06:02/DQA1*03:01-DQB1*03:02) genotype is protective.
|
30626607 |
2019 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
A strong positive association of DRB1*04-DQA1*0301-DQBl*0302 (OR=5.67, p<0.001) and DRB1*0301-DQA1*0501-DQB1*0201 (OR=6.24, p<0.001) putative haplotypes with IDDM was evident in Jordanian IDDM patients whereas DRB1*1101-DQA1*0505- DQB1*0301 (OR=0.23, p=0.03) was shown to have a protective role against T1D in Jordanians.
|
31742498 |
2019 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD).
|
31331105 |
2019 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG sites within the MHC genes (cis-metQTLs) between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and HLA-DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8).
|
29224923 |
2018 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
The association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQα-β heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes.
|
29088299 |
2017 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Participants were aged 1-24 years.T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4.
|
28808665 |
2017 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).
|
28247576 |
2017 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
Genotypes generated by the association of markers Arg52 DQA1 positive and Asp57 DQB1 negative increase T1D susceptibility much more than one would expected by a simple additive effect of those markers separately (OR = 26.9).
|
28834219 |
2017 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10<sup>-</sup><sup>7</sup>), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10<sup>-</sup><sup>6</sup>), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10<sup>-4</sup>) and to type 1 diabetes (p = 4.6 × 10<sup>-11</sup>).
|
29066732 |
2017 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
We also confirm that genetic susceptibility to T1D is associated with the DRB1*03:01-DQA1*05:01-DQB1*02:01 and DRB1*04-DQA1*03:01-DQB1*03:02 haplotypes in Brazilian northeast region.
|
26492519 |
2016 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up.
|
26822082 |
2016 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
PosttranslationalModification |
BEFREE |
Our aim was to investigate DNA methylation of HLA-DQA1 promoter alleles (QAP) and correlate methylation status with individual HLA-DQA1 allele expression of patients with T1D and healthy controls.
|
26854762 |
2016 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
The strongly associated T1D haplotype DRB1*0301-DQA1*05-DQB1*0201 is also associated with LADA but confers only half of the T1D risk (odds ratio 2.65 vs 4.84).
|
26866570 |
2016 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
High levels of significance were obtained to support higher T1D risk when harbouring DQA1*03:01.
|
26095634 |
2015 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Our results showed significant association of 10 single nucleotide polymorphisms (SNPs) with T1D at p<0.01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more SNPs showed their association at 0.01<p<0.05 in Pakistani population.
|
25661663 |
2015 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
CTD_human |
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
|
26168013 |
2015 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
Susceptibility to type 1 diabetes (T1D) is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02).
|
25405480 |
2014 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Among the various haplotypes tested, the DQA1*0201:DQB1*020101G, DQA1*050101:DQB1*020101G, and DQA1*0201:DQB1*030101G were the most frequently found in T1DM patients.
|
23121162 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc transporter 8 (ZnT8WA), glutamine zinc transporter 8 (ZnT8QA), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), HLA-DQA-B1 genotypes, thyroid-stimulating hormone (TSH) and free thyroxine (T4).
|
23666211 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
Notably, the African-specific "DR3" haplotype DRB1*03:02-DQA1*04:01-DQB1*04:02 is protective for type 1 diabetes, in contrast to the common and highly-susceptible DR3 DRB1*03:01-DQA1*05:01-DQB1*02:01.
|
23801574 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
The present study found a significant SNP rs7990 of HLA-DQA1 (p = 0.009) negative correlation, again indicating that risk from HLA is considerably more with T1DM.
|
23441825 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation |
BEFREE |
Owing to strong linkage disequilibrium between markers, pinpointing disease associations within genetic regions is difficult in European ancestral populations, most notably the very strong association of the HLA-DRB1*03-DQA1*05:01-DQB1*02:01 haplotype with Type 1 diabetes risk, which is assumed to be because of a combination of HLA-DRB1 and HLA-DQB1.
|
23398374 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
The notable difference was the identification of DRB1*16-DQA1*0102-DQB1*0501 as a protective haplotype and the absence of a negative association of DRB1*1301-DQA1*0103-DRB1*0603 with T1D.
|
22583516 |
2013 |
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker |
BEFREE |
The type 1 diabetes high-risk HLA-DQ A1*05:01-B1*02:01/A1*03:01-B1*03:02 genotype along with lower risk DQ genotypes were determined at the time of clinical onset by PCR and hybridization with allele-specific probes.
|
21712811 |
2012 |