|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We found TCR sequences that were used in multiple library wells from patients with T1D, but these sequences were private and not shared between individuals.
|
30082321 |
2018 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
AlteredExpression |
BEFREE |
However, faster STAT3 activation after TCR stimulation without concomitant increase in IL-6 expression was observed in T cells from patients with T1D.
|
30006377 |
2018 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Overall, KLRG1 expression delineates a subpopulation of dysfunctional T<sub>reg</sub> cells during T1D progression in autoantigen-specific TCR transgenic NOD mice.
|
28850267 |
2017 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In this study, we directly compared the clonal iNKT repertoire of people with recent onset type 1 diabetes and age- and gender-matched healthy controls with regard to iNKT-TCR affinity and cytokine production.
|
28062695 |
2017 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
This study demonstrates the potential of TCR gene transfer to develop islet-specific Treg therapies for effective treatment of T1D, but also highlights that additional optimisation may be required to achieve its full potential.
|
28117148 |
2017 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
There are skewd genes in TCR Vα and TCR Vβ, which are probably relative to the onset of T1D.
|
26479550 |
2016 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire.
|
20644174 |
2010 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
These results provide evidence that new-onset patients with type 1 DM and healthy controls are primed against CVB4, and that CD4 T cell responses to the virus have a selective TCR Vbeta chain usage which is driven by viral Ags rather than a superantigen.
|
11544345 |
2001 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We propose that a primary deficiency in human type 1 diabetes is a defect in TCR/CD3-mediated T cell activation due to the abnormal expression of the p56(lck) tyrosine kinase.
|
11067948 |
2000 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We have overcome these difficulties by coupling a simplified TCR transgenic (tg) model of IDDM and the immunosuppressive drug cyclophosphamide (CY).
|
9933106 |
1999 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Double transgenic (dTg) mice expressing the hemagglutinin (HA) of influenza virus under the insulin promoter and the TCR specific for the immunodominant CD4 T cell epitope of HA (HA110-120) develop insulin-dependent diabetes mellitus (IDDM).
|
10524496 |
1999 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
AlteredExpression |
BEFREE |
These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM.
|
10075863 |
1999 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In order to clarify the nature of T lymphocytes infiltrating the pancreatic islets of patients with insulin-dependent diabetes mellitus (IDDM), we analysed T cell receptor (TCR) gene transcripts expressed in pancreatic biopsy specimens of patients with recent-onset IDDM.
|
8968689 |
1996 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls.
|
1982251 |
1991 |
|
TRBV20OR9-2
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We investigated the T cell receptor constant beta chain (TCR C beta) genes of patients with insulin dependent diabetes mellitus (IDDM) using DNA restriction fragment length polymorphism (RFLP) analysis.
|
2891459 |
1987 |