|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We then found that circulating CILP-2 levels had a progressive increase from normal to IGT (a pre-diabetic status) and then to diabetes, which was correlated positively with WHR, triglyceride, FBG, 2-h blood glucose after glucose overload (2h-BG), HbA1c, FIns, 2h-Ins, and HOMA-IR but negatively with HDL-C. CILP-2 expression was increased in the liver and muscle but decreased in adipose tissues of obese mice or T2DM patients.
|
30896018 |
2019 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In exclusively IGT or T2D cohorts, beta cell insulin secretion was found to be lower in BA compared to WE.
|
31781667 |
2019 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
In this randomized crossover study, subjects with IGT-A (n=15, BMI: 32.4±5.2kg/m<sup>2</sup>), IGT-B (n=20, BMI: 32.5±5kg/m<sup>2</sup>) or T2D (n=12, BMI: 32.2±5.2kg/m<sup>2</sup>) followed a weight-maintenance diet (45% carbohydrates, 20% proteins, 35% fats) in 3 or 6 meals/day (each intervention lasting 12 weeks).
|
29680359 |
2018 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression |
BEFREE |
Five years postpartum impaired glucose regulation (IFG, IGT, or diabetes) was diagnosed in 15% of the women; 3.6% had type 2 diabetes.
|
29460080 |
2018 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Lifestyle interventions significantly improved FPG, HbA1c, FI, HOMA-IR, and bodyweight among adults without IGT or diabetes, and might reduce progression of hyperglycemia to type 2 diabetes mellitus.
|
28024276 |
2017 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
The 876 Nordic women with PCOS, aged 14-57 years, were examined for T2D and prediabetes (impaired glucose tolerance [IGT] or impaired fasting glucose (IFG) by OGTT.
|
29040530 |
2017 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
The ratio of IAPP/C-peptide during the first (225 mg/dl) and second step (400 mg/dl), and in response to arginine, was decreased in T2DM versus both NGT and IGT (p < 0.01).
|
27624579 |
2017 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Serum microRNA-126 expression could be a good marker for diagnosis of IGT and T2DM as well as for monitoring the outcomes of such disease.© 2016 IUBMB Life, 68(6):452-458, 2016.
|
27118517 |
2016 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Among the total of 142 participants, 73 subjects with no family history of T2DM (FH-) included 42 with normal glucose tolerance (NGT/FH-) and 31 with impaired glucose tolerance (IGT/FH-); and 69 first-degree relatives of patients with T2DM (FH+) included 36 with NGT (NGT/FH+) and 33 with IGT (IGT/FH+).
|
22543593 |
2013 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre-diabetes individuals (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) and 19 cases of T2D-susceptible individuals with normal glucose tolerance (s-NGT).
|
20857148 |
2011 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
IFG and IGT identified in general practice during a stepwise, high-risk screening programme for type 2 diabetes have high 1-year progression rates to diabetes.
|
17143605 |
2007 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Oral glucose tolerance testing identified subjects with previously undiagnosed prediabetes (IFG, IGT) and type 2 diabetes.
|
16969647 |
2006 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Among 13 LD blocks constructed, an LD block at the 5'-region showed a significant difference in the haplotype distribution between the study groups (NGT vs. IGT + DM: overall p = 0.0180; NGT vs. DM: 0.0001).
|
15721294 |
2005 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
The common polymorphisms of the IGF-1R, IRS-1 and IRS-2 genes may modify the weight change response to a lifestyle intervention but not the conversion from IGT to Type 2 diabetes, whereas IGF-1R may also regulate the risk of developing Type 2 diabetes.
|
15127203 |
2004 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We also examined the potential impact of the class III allele in genotype-quantitative trait studies in three Danish study populations containing (i) 358 young healthy subjects; (ii) 4444 middle-aged NGT subjects, 490 subjects with IFG and 678 subjects with IGT; and (iii) 221 NGT subjects, of whom one parent had Type 2 diabetes.
|
15170498 |
2004 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
Multiple logistic regression analysis also showed that the genotypes with the D allele were risk factors for DM and IGT even when adjusting for age, sex, hypertension and serum total cholesterol levels (odds ratio 1.49, 95% CI 1.01-2.21).
|
14599112 |
2003 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
The incidence of Type II diabetes and IGT among the Swedish subjects at the age of 70 was similar in the three genotype-groups of the Pro12Ala variant and the Ala-allele was not related to a lower prevalence of Type II diabetes in Danish Caucasians.
|
11596673 |
2001 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In conclusion, aberrant phosphorylation/activity of IRS-1, PI 3-kinase, and Akt is observed in skeletal muscle from relatives of patients with type 2 diabetes with IGT.
|
11723060 |
2001 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
Despite these uncertainties, the weight of current evidence supports the view that insulin resistance is very important in the etiology of typical NIDDM for the following reasons: 1) it is found in the majority of patients with the manifest disease; 2) it is only partially reversible by any form of treatment (117); 3) it can be traced back through earlier stages of IGT and high-risk conditions; and 4) it predicts subsequent development of the disease with remarkable consistency in both prediabetic and normoglycemic states.
|
9715376 |
1998 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In fact, the literature better supports the case of impaired insulin secretion being the initial and main genetic factor predisposing to type 2 diabetes, especially 1) the studies in people at high risk to subsequently develop type 2 diabetes (discordant monozygotic twins and women with previous gestational diabetes), 2) the studies demonstrating compete alleviation of insulin resistance with weight loss, and 3) the studies finding that people with type 2 diabetes or IGT can have impaired insulin secretion and no insulin resistance compared with well matched NGT subjects.
|
9715377 |
1998 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
While none of these variants were significantly associated with IGT or NIDDM, a nonsignificant increase in the beta-cell promoter variant was observed in subjects with abnormal glucose tolerance.
|
7882822 |
1994 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In conclusion, this study has demonstrated that in South-African Indians with IGT, the majority (50.4%) progress to NIDDM within 4 yr; significant predictors of subsequent diabetes are the baseline fasting and 2-h plasma glucose concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8454106 |
1993 |
|
LOC102723407
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
We compared the prevalence of NIDDM and IGT for 4914 subjects according to their parental history of diabetes (mother only, father only, both parents, neither parent).
|
8404430 |
1993 |