|
SERPINE1
|
Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
We noted that statins reduced TGF-β activity, cell viability and invasiveness, Rho/ROCK activity, phosphorylation and activity of the TGF-β mediator Smad3, and expression of TGF-β targets ZYX and SERPINE1 in GBM and GBM-initiating cell (GIC) lines.
|
30899443 |
2019 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
Together, our results indicate that SERPINE1 is a key player in GBM dispersal and provide insights for future anti-invasive therapy design.
|
31731490 |
2019 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
Yet, there is little contemporary data on the differential expression of TGF-β isoforms at the mRNA and protein level or TGF-β/Smad pathway activity in glioblastomas in vivo.Here we studied 64 newly diagnosed and 16 recurrent glioblastomas for the expression of TGF-β1-3, platelet-derived growth factor (PDGF)-B, and plasminogen activator inhibitor (PAI)-1 mRNA by RT-PCR and for the levels of TGF-β1-3 protein, phosphorylated Smad2 (pSmad2), pSmad1/5/8 and PAI-1 by immunohistochemistry.Among the TGF-β isoforms, TGF-β1 mRNA was the most, whereas TGF-β3 mRNA was the least abundant.
|
25849941 |
2015 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study supporting an association of the PAI-1 4G/5G (p=0.01824) and A-844G (p=0.02012) polymorphisms with increasing glioblastoma cancer risk in Iranian patients.
|
26434837 |
2015 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1.
|
24305710 |
2014 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
Collectively, these results indicate that S1P and IL-1 activate distinct pathways leading to the mRNA and protein expression of PAI-1 and uPAR, which are important for glioblastoma invasiveness.
|
18819934 |
2008 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
LHGDN |
Collectively, these results indicate that S1P and IL-1 activate distinct pathways leading to the mRNA and protein expression of PAI-1 and uPAR, which are important for glioblastoma invasiveness.
|
18819934 |
2008 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
|
17855624 |
2008 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
These results suggest that EGR-1 may regulate cell interaction with the extracellular matrix by coordinated induction of TGF-beta1, FN, and PAI-1 in human glioblastoma cells.
|
10783396 |
2000 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
Recent evidence has shown a correlation between the presence of tumor necrosis and low content of tissue plasminogen activator in brain tumors and significantly higher levels of plasminogen activator inhibitor-1 (PAI-1) in human glioblastomas.
|
7731519 |
1995 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
These results suggest that high expression of PAI-1 is associated with the malignant progression of astrocytic tumors and that excessive PAI-1 expression might be associated with intratumoral necrosis in glioblastomas.
|
8012944 |
1994 |
|
SERPINE1
|
Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
In addition to these cell-bound components, the glioblastoma cells also secreted two inhibitors that formed complexes with 125I-urokinase; one was PAI-1, and the other was PN-1.
|
1987320 |
1991 |