Both essential oils showed activity against grade IV glioma cell lines (IC<sub>50</sub> = 400 <i>μ</i>g/mL), antimicrobial (MIC and MFC values of 2500 to 125 <i>μ</i>g/mL), and anti-inflammatory (decreased level of IL-1<i>β</i>, IL-6, TNF-<i>α</i>, and IFN-<i>γ</i> in LPS-stimulated cells).The essential oils exhibited moderate antioxidant activity in ABTS (EC<sub>50</sub> = 98 and 88 <i>μ</i>g/mL) assay.
The distal breakpoints of the deletions (in relation to the centromere) in 14 glioma and leukemia cell lines have been mapped within the 400 kb IFN gene cluster located at band 9p21.
Ten of 15 (67%) glioma-derived cell lines had hemizygous or homozygous deletion of IFN genes or rearrangement of sequences around these genes, while 13 of 35 (37%) primary glioma tumor samples had hemizygous (8 tumors) or homozygous (5 tumors) deletion of the IFN genes.