Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0017921
Disease: Glycogen storage disease type II
Glycogen storage disease type II 		0.040 GeneticVariation BEFREE Mean concentrations of cytokines in aqueous humour in patients with neovascular AMD before the first and third ranibizumab injections were as follows (in pg/mL): CXCL1, 8.4 and 3.3; IP-10, 110 and 55; CXCL12, 480 and 240; CXCL13, 9.2 and 2.6; MCP-1, 620 and 220; CCL11, 7.1 and 2.8; IL-6, 5.9 and 1.6; IL-10, 0.15 and 0.015 (all p<0.0001), and MMP-9, 0.92 and 1.5 (p=0.0216), respectively. 28765149

2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0017921
Disease: Glycogen storage disease type II
Glycogen storage disease type II 		0.040 GeneticVariation BEFREE CCL2 single nucleotide polymorphism of rs1024611 implicates prominence of inflammatory cascade by univariate modeling in Indian AMD. 29664944

2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0017921
Disease: Glycogen storage disease type II
Glycogen storage disease type II 		0.040 Biomarker BEFREE CCL2/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD. 24142887

2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0017921
Disease: Glycogen storage disease type II
Glycogen storage disease type II 		0.040 Biomarker BEFREE Other murine models target genes relevant to AMD, including inflammatory genes such as Cfh(-/-), Ccl2(-/-), Ccr2(-/-), Cx3cr1(-/-), and Ccl2(-/-)/cx3cr1(-/-), oxidative stress associated genes such as Sod1(-/-) and Sod2 knockdown, metabolic pathway genes such as neprilysin(-/-) (amyloid beta), transgenic mcd/mcd (cathepsin D), Cp(-/-)/Heph(-/Y) (ferroxidase ceruloplasmin/hepaestin, iron metabolism), and transgenic ApoE4 on high fat and high cholesterol diet (lipid metabolism). 20206286

2010