Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 GeneticVariation BEFREE Hyperglycaemia in pregnant rats causes sex-related vascular dysfunction in adult offspring: role of cyclooxygenase-2. 28556994

2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 AlteredExpression BEFREE Taken together, these results demonstrate that hyperglycemia-induced hepatic apoptosis is protected by hCOX-2 expression. 23059845

2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 AlteredExpression BEFREE Changes in expression of IL1B, early growth response gene 3, and prostaglandin-endoperoxide synthase 2 resolved within 4 months of insulin therapy and were also observed in T2D, suggesting that they resulted from hyperglycemia. 17595242

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 Biomarker LHGDN Given that hyperglycemia has been reported to increase human beta-cell production of interleukin-1beta and that this cytokine can induce COX-2 expression, our observations of glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction. 14749287

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 AlteredExpression LHGDN Our results suggest that hyperglycemia increases mitochondrial ROS production, resulting in NF-kappaB activation, COX-2 mRNA induction, COX-2 protein production, and PGE2 synthesis. 14514642

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.350 Biomarker CTD_human Our results suggest that hyperglycemia increases mitochondrial ROS production, resulting in NF-kappaB activation, COX-2 mRNA induction, COX-2 protein production, and PGE2 synthesis. 14514642

2003