Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker CTD_human Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. 24795235

2014
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker LHGDN These results suggest that PAR-2 may be involved in allergic nasal inflammation. 17727088

2007
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker LHGDN Thus, trypsin IV and p23 are inhibitor-resistant trypsins that can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent inflammation and PAR(2)-dependent hyperalgesia. 17623652

2007
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker LHGDN PAR2 has been demonstrated to play a role during inflammation and immune response in different tissues including the skin. 16470180

2006
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker LHGDN Recent knowledge indicates that PAR2 is involved in cutaneous inflammation and immune response. 15654951

2005
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.340 Biomarker CTD_human Taken together our data show that both NO and capsaicin-sensitive afferent neurons are involved in PAR-2-mediated colonic inflammation and paracellular permeability increase. 12682265

2003