Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 GeneticVariation BEFREE In this pilot exploratory study, the primary aim was to determine whether genetic polymorphisms of tryptophan hydroxylase ( TPH1/TPH2), serotonin reuptake transporter ( SERT), or catechol-O-methyltransferase ( COMT) are associated with fatigue in women with IBS. 30309244

2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 GeneticVariation BEFREE It is unknown whether this COMT polymorphism is associated with symptom improvements in patients with IBS. 28252569

2017
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 GeneticVariation BEFREE Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients. 25722948

2015
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 Biomarker BEFREE In contrast, compared with control subjects, COMT 158Met was significantly more prevalent in the IBS group (P=0.040) and significantly more prevalent in patients with diarrhea (P=0.029). 25037115

2014
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 GeneticVariation BEFREE In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). 23110189

2012
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.060 GeneticVariation BEFREE In this study we found an association between the val/val genotype of the val158met COMT gene and IBS as well as to specific IBS related bowel pattern in IBS patients. 21437260

2011