|
HLA-DRB1
|
Arthropathy
|
0.070 |
GeneticVariation |
BEFREE |
We tested validated susceptibility variants - 69 single-nucleotide polymorphisms (SNP), 15 HLA-DRB1 alleles, and amino acid polymorphisms in 6 HLA molecule positions - for their associations with progression in Larsen scoring, 28-joint Disease Activity Scores, and Health Assessment Questionnaire (HAQ) scores over 2 years using linear mixed-effects and latent growth curve models.
|
25979711 |
2015 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
GeneticVariation |
BEFREE |
Each patient participated in a comprehensive assessment that included ascertainment of age, sex, joint tenderness and swelling, subcutaneous nodules, disease severity, use of methotrexate and prednisone, smoking status, rheumatoid factor (RF), antibodies against cyclic citrullinated peptide (anti-CCP),erythrocyte sedimentation rate (ESR), the 28-joint Disease Activity Score (DAS28), and the presence of the HLA-DRB1 shared epitope (SE).
|
26255186 |
2015 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
Biomarker |
BEFREE |
To describe the pattern of arthropathy and HLA-DRB1 alleles associated with PMR in order to develop a diagnostic algorithm that could help distinguish PMR and RF-negative (RF -ve) late-onset RA (LO-RA) at presentation.
|
18980958 |
2009 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
Biomarker |
BEFREE |
HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis.
|
17223660 |
2007 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
Biomarker |
BEFREE |
The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis.
|
16277691 |
2005 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
GeneticVariation |
BEFREE |
Type 1 arthropathy was associated with HLA-DRB1*0103 (DR103; a rare subtype of DR1) in 33% (P < 0.0001; relative risk [RR], 12.1), B*35 in 30% (P = 0.01; RR, 2.2), and B*27 in 26% (P = 0.001; RR, 4.0).
|
10648455 |
2000 |
|
HLA-DRB1
|
Arthropathy
|
0.070 |
Biomarker |
BEFREE |
In the light of associations previously described between DR4, DQw7, the C4B null allele and Felty's syndrome, and between Dw14, the C4A null allele and rheumatoid vasculitis, we have looked for associations between these and other DRB1, DQB, DQA and C4 encoded variants, and articular disease severity assessed radiologically in 119 subjects with RA but without major extra-articular features.
|
8401999 |
1993 |