Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 GeneticVariation BEFREE Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women. 30289892

2018
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 GeneticVariation BEFREE To evaluate the role of polymorphisms in genes TLR1, TLR2 and TLR4 and susceptibility to leprosy in a genetic case control study; to verify the association between genotypes of these markers and the immunological profile in the serum of patients with leprosy. 28327786

2017
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 Biomarker BEFREE Our results suggest that TLR1 248S is associated with an increased risk for leprosy, consistent with its hypoimmune regulatory function. 23547143

2013
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 GeneticVariation BEFREE We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54). 20617178

2010
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 GeneticVariation BEFREE Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. 19456232

2009
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 GeneticVariation BEFREE We hypothesized that this TLR1 SNP regulates the innate immune response and susceptibility to leprosy. 18461142

2008
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 Biomarker BEFREE Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. 17548585

2007
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy 		0.370 Biomarker CTD_human