Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 GeneticVariation BEFREE These results showed that AA has a weak mutagenic effect at HPRT gene locus in human promyelocytic leukaemia HL-60 and NB4 cell lines and those molecular mutation spectra (single exon deletions and point mutations) may be related to some specific and precise mechanism. 18407966

2008
Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 GeneticVariation BEFREE In this review, I will present the utility of analyzing mutagenic V(D)J recombinase mediated genomic rearrangements at the HPRT locus in humans as an in vivo model system for understanding the mechanisms responsible for leukemogenic genetic alterations observed in children with leukemia. 16807138

2006
Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 GeneticVariation BEFREE Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone. 16838078

2006
Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 AlteredExpression LHGDN Analysis of genetic alterations and clonal proliferation in children treated for acute lymphocytic leukemia. 16951156

2006
Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 GeneticVariation BEFREE We now demonstrate that the HPRT gene can be utilized to detect mutations in myeloid stem cells, which are frequent progenitor cells of leukemias. 10635986

1999