Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia 		0.040 AlteredExpression BEFREE The in vitro effects of interferon-alpha (IFN) on levels of secreted interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF alpha), and nuclear matrix proteins (NMP) were examined in ESKOL, a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL). 11755467

2002
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia 		0.040 Biomarker BEFREE Incubation of PBMCs with IFN-alpha resulted in a significant increase of intracellular IL-6 in HCL but not in healthy donors. 8840984

1996
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia 		0.040 Biomarker BEFREE IL-6 production by HCL-O cells may be induced or enhanced by EBV, and the secreted IL-6 might play a role in their own growth or differentiation. 7985490

1994
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia 		0.040 Biomarker BEFREE Interferon alpha (IFN-alpha) abrogates TNF- or IL-6-induced proliferation of HCL and B-CLL cells in vitro and has therapeutic activity in these diseases. 2258703

1990