Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker BEFREE FXR-agonists target both the gut and the liver and are currently being tested in different liver diseases. 31622696

2020
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker BEFREE And FXR has been well investigated in liver diseases. 31308634

2019
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker BEFREE We have identified an FXR/β-catenin interaction whose modulation through β-catenin suppression promotes FXR activation and decreases hepatic BAs, which may provide unique therapeutic opportunities in cholestatic liver diseases.(Hepatology 2018;67:955-971). 28714273

2018
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker BEFREE IRE1α/XBP1 pathway activation by bile acids and pharmacological FXR agonists may be protective during liver injury and may have therapeutic implications for liver diseases.(Hepatology 2018;68:304-316). 29377207

2018
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker BEFREE Failure of the urea cycle and hyperammonemia are common in patients with acute and chronic liver diseases; compounds that activate FXR might promote ammonium clearance in these patients. 28130067

2017
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker CTD_human Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice. 22130247

2011
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 AlteredExpression BEFREE Cell type-specific FXR protein expression was determined by immunohistochemistry in five mouse models and prototypic human fibrotic liver diseases. 19910507

2009
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker LHGDN The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor. 18668687

2008
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.380 Biomarker LHGDN Nuclear bile acid receptor farnesoid X receptor meets nuclear factor-kappaB: new insights into hepatic inflammation. 18972560

2008