Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker BEFREE In this study, we demonstrated that necrosis-inducing peptide P16 kills human glioblastoma cancer cells and primary human hepatoma or renal cancer cells isolated from patients who had not responded to standard treatments. 31206614

2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker CTD_human Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. 27064257

2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker BEFREE In summary, a senescence-inducing program was found in hepatocytes with increased β-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice). 25270420

2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 PosttranslationalModification BEFREE Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiation of hepatocellular carcinoma (HCC) from other liver tumors. 20569442

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 AlteredExpression BEFREE Intriguingly, we found no evidence that Bmi1 regulates Ink4A/Arf expression in both in vitro and in vivo systems of liver tumor development. 19934271

2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 AlteredExpression BEFREE Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. 18949401

2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker RGD Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker CTD_human Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 AlteredExpression BEFREE Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. 15619210

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker BEFREE Additionally, we analysed the methylation status of p16(INK4a) and other cancer-related genes in the same liver tumors. 12660822

2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker CTD_human Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver. 12378512

2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker RGD De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. 12359353

2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker RGD Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma. 11301474

2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 GeneticVariation BEFREE p16INK4a and beta-catenin alterations in rat liver tumors induced by NNK. 11238187

2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker BEFREE There were no deletions of p16 and p15 in any of the hepatoma cell lines. 9058294

1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.690 Biomarker HPO