Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 Biomarker BEFREE These results indicate that CS-induced HMGB1 translocation and release contribute to migration and NF-κB activation through inducing autophagy in lung macrophages, providing novel evidence for HMGB1 as a potential target of intervention in COPD. 31769590

2020
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 Biomarker BEFREE Logistic regression showed that HMGB1 was identified to be independent risk factor for T2DM combined with COPD. 31129918

2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 Biomarker BEFREE Thus, the protective effect of ulinastatin in the lungs of rats with COPD is associated with changes in the HMGB1/TLR4 signaling pathway. 30128028

2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 AlteredExpression BEFREE HMGB1 expression was increased in A. fumigatus-infected COPD alveolar macrophages. 29078091

2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 Biomarker BEFREE The top differentially expressed gene was HMGB1, which interacts with AGER, a known COPD GWAS gene. 28287180

2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.060 Biomarker BEFREE Remodelled vessels present in COPD with PH and IPAH lung samples were often surrounded by HMGB1-positive cells. 25726846

2015