Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE Estrogen receptor alpha (ERα) knockout (KO) mice are used for defining hormone receptor effects in lupus. 30416032

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE Our laboratory previously backcrossed "estrogen receptor alpha knockout (ERαKO)" mice onto the NZM2410 lupus prone background to generate NZM/ERαKO mice. 28822833

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE The choice of inhibitors of transcription factor NF-κBp65 and selective modulators for estrogen receptor alpha are proposed areas of lupus drug discovery research. 27290913

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE Estrogen receptor alpha promotes lupus in (NZB×NZW)F1 mice in a B cell intrinsic manner. 27989899

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 AlteredExpression BEFREE We have previously observed that expression of ERα gene and protein in lupus patients is significantly higher than in healthy controls and that estradiol up-regulates calcineurin expression via over-expression of ERα gene in SLE. 24861435

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE A model is proposed that suggests estrogen, acting through the estrogen receptor, enhances T cell activation in women with lupus resulting in amplified T-B cells interactions, B cell activation and autoantibody production. 11407298

2001

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 Biomarker BEFREE Molecular analysis of estrogen receptor alpha and beta in lupus patients. 11168443

2001

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.080 AlteredExpression BEFREE Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells. 9676761

1998