|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
Biomarker |
BEFREE |
The IGHV gene repertoire was remarkably biased in FL.
|
31209206 |
2019 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
IGHV mutation analysis showed that all FL-B-LBL pairs harbored identical or near-identical somatic mutations.
|
27750045 |
2016 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
Biomarker |
BEFREE |
In conclusion, our results indicate that analysis of IGHV gene usage might aid in predicting prognosis for FL patients.
|
25900812 |
2015 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
AlteredExpression |
BEFREE |
Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas.
|
21790530 |
2011 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
AlteredExpression |
BEFREE |
Our findings demonstrate that follicular lymphomas without BCL-2 gene rearrangement and expression are associated with ongoing somatic hypermutation of the IGVH genes, low activity of aberrant somatic hypermutation and elevated activation-induced cytidine deaminase expression.
|
18945749 |
2008 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a high incidence of novel N-glycosylation sites introduced by somatic mutation was observed in the immunoglobulin variable region genes of follicular lymphoma.
|
12542478 |
2003 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.
|
11895794 |
2002 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma.
|
9602371 |
1998 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes.
|
8043433 |
1994 |
|
LOC102723407
|
Lymphoma, Follicular
|
0.100 |
GeneticVariation |
BEFREE |
To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient.
|
1495966 |
1992 |