DisGeNET - a database of gene-disease associations

Source: ALL

Disease: Malignant neoplasm of stomach ×

Gene: PFKFB3 ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	5209
Gene Symbol:	PFKFB3

PFKFB3

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

Biomarker

BEFREE

Our results suggest that targeting PRKD3/p65/PFKFB3 cascade maybe a promising therapeutic strategy for gastric cancer.

31026442

2019

Entrez Id:	5209
Gene Symbol:	PFKFB3

PFKFB3

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

Biomarker

BEFREE

Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.

27983531

2017

Entrez Id:	5209
Gene Symbol:	PFKFB3

PFKFB3

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

AlteredExpression

BEFREE

The basal level of PFKFB-4 protein expression in gastric cancers was much higher as compared to the PFKFB-3 isoenzyme.

17143338

2006