Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas. 29904909

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE A majority of mesothelioma lacks p14 and p16 expression, which leads to defective p53 pathway despite bearing the wild-type p53 genotype. 29899847

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE Metformin suppressed cell growth of 9 kinds of mesothelioma including immortalized cells of mesothelium origin irrespective of the p53 functional status, whereas susceptibility to nutlin-3a was partly dependent on the p53 genotype. 28464864

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE We examined whether zoledronic acid (ZOL), a third generation bisphosphonate, and adenoviruses with a deletion of the E1B-55kD gene (Ad-delE1B55), which augments p53 levels in the infected tumors, could produce combinatory anti-tumor effects on human mesothelioma cells bearing the wild-type p53 gene. 27405588

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE We observed constitutive activation of FAK, a known negative regulator of p53, in each of 10 mesothelioma cell lines and each of nine mesothelioma surgical specimens, and FAK was associated with p53 in five of five mesothelioma cell lines. 27736841

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE Included are seven cell lines with wild-type p53 (four mesothelioma, one breast cancer, one chondrosarcoma, and one leiomyosarcoma), two liposarcoma cell lines harboring MDM2 amplification and wild-type p53, and one mesothelioma cell line harboring a p53 point mutation. 27129163

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE 17 miRNAs regulating TP53, 18 miRNAs regulating MDM2, and 11 miRNAs directly regulating CDKN2A are significantly downregulated in MDM2-expressing mesotheliomas. 26918730

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE NF2 blocks Snail-mediated p53 suppression in mesothelioma. 25823924

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE In control mesothelioma cell lines, HDACi treatment resulted in down-regulation of p53 in the p53 mutant cell line JMN1B, but resulted in no changes of MDM2 and p53 in two mesothelioma lines with normal MDM2 and wild-type p53. 25888633

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE We developed a new mouse model of mesothelioma by bladder or intraperitoneal injection of adenovirus Cre into mice with conditional alleles of each of Tp53 and Tsc1. 23851502

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE We examined whether forced expression of p53 inhibited growth of mesothelioma cells and produced anti-tumor effects by a combination of cisplatin (CDDP) or pemetrexed (PEM), the first-line drugs for mesothelioma treatments. 22223137

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker LHGDN p53-induced apoptosis occurs in the absence of p14(ARF) in malignant pleural mesothelioma. 16867217

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE We have found frequent inactivations of p16/Cdkn2a, p19/Arf (or P14/ARF) and p15/Cdkn2b, coinactivation of p16/Cdkn2a and p15/Cdkn2b and low rate of Trp53 mutations in both asb-Nf2(KO3/+) and asb-Nf2(+/+) mesothelioma cells. 16319530

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE However, the function of p53 has not been investigated in mesothelioma cells. 12569381

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE Asbestos appears to increase SV40-mediated transformation of human mesothelial cells in vitro, suggesting that asbestos and SV40 may be cocarcinogens. p53 mutations are rarely found in mesothelioma; p16, p14ARF, and NF2 mutations/losses are frequent. 11836664

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker CTD_mouse Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice. 12151629

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE Our results suggest that human mesotheliomas with wild-type p53 yet lacking p14(ARF) are potential candidates for ONYX-015 therapy. 11507034

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE Homozygous deletion of the INK4a/ARF locus is common in human mesothelioma and may result in the loss of p14(ARF) and the inactivation of p53. 10772681

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE These results and the results reported by others indicate that the K-ras proto-oncogene and p53 tumor suppressor gene may not play a critical role in the induction of mesothelioma by asbestos either in humans or in rats. 10863160

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE Adenovirus-mediated wild-type p53 overexpression reverts tumourigenicity of human mesothelioma cells. 10812006

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE Paraffin sections from 11 mesotheliomas were used for p53 immunostaining and also to extract DNA. 10474522

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE DNA-like sequences of the p53 and pRB-inactivating simian virus 40 large T-antigen (SV40 LTag) have recently been found in mesotheliomas in the United States and several European countries. 10431839

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker BEFREE We investigated whether the expression of the SV40 large T-antigen (Tag) interferes with the normal expression of the tumor suppressor gene p53 in human mesotheliomas. 9256284

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 GeneticVariation BEFREE In this study, a search was done for mutations in the conserved regions of the p53 gene in malignant mesotheliomas. 8998073

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 AlteredExpression BEFREE In order to determine the relationship between mutations, tissue accumulations, and serum levels of p53 in occupational cancers, we used denaturing gradient gel electrophoresis and DNA sequencing of exons 5-9 of the p53 gene, immunohistochemical analysis for tissue identification of mutant p53 protein, and enzyme-linked immunosorbent assay for serum levels of mutant p53 protein to examine for such alteration in a cohort of individuals with workplace exposure to asbestos or silica, and resultant lung cancers or mesotheliomas. 9329647

1997