Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker BEFREE The concentrations of free Gc-globulin in plasma collected from patients diagnosed with AD (509.6 ±87.6 mg/L) and ALS (455.5 ±99.8 mg/L) did not differ significantly between each other, but were significantly higher compared to the reference group (311.7 ±87.5 mg/L) (p < 0.001 and p < 0.006, respectively) as well as to MS (310.8 ±66.6 mg/L) (p < 0.001 and p < 0.001, respectively) and TBE (256.7 ±76 mg/L) (p < 0.001 and p < 0.003, respectively). 29905407

2018
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker BEFREE Vitamin D-binding protein and multiple sclerosis: Evidence, controversies, and needs. 30113253

2018
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation BEFREE Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis. 29414925

2018
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker BEFREE CF = cystic fibrosis DBP = vitamin D binding protein ELISA = enzyme-linked immunosorbent assay ESLD = end-stage liver disease HC = hormone contraceptives iPTH = intact parathyroid hormone LC-MS = liquid chromatography-mass spectrometry MS = multiple sclerosis 25(OH)D = 25-hydroxyvitamin D PHPT = primary hyperparathyroidism RIA = radioimmunoassay. 28095044

2017
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation BEFREE In conclusion, our findings do not support a role of an independent effect of the investigated vitamin D-related gene variants, VDBP and CYP27B1, in the risk of MS. 27904983

2017
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker CTD_human Increased circulating levels of vitamin D binding protein in MS patients. 25590278

2015
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker BEFREE The emerging role of vitamin D binding protein in multiple sclerosis. 21042807

2011
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation BEFREE We found no clear association between MS and frequencies of phenotypes or alleles of Gc protein. 3218452

1988