DisGeNET - a database of gene-disease associations

Source: ALL

Disease: Multiple Sclerosis ×

Gene: IL12A ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	3592
Gene Symbol:	IL12A

IL12A

CUI:	C0026769
Disease:	Multiple Sclerosis

Multiple Sclerosis

0.320

Biomarker

CTD_human

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

24076602

2013

Entrez Id:	3592
Gene Symbol:	IL12A

IL12A

CUI:	C0026769
Disease:	Multiple Sclerosis

Multiple Sclerosis

0.320

GeneticVariation

BEFREE

Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk factors for multiple sclerosis (MS).

21716315

2012

Entrez Id:	3592
Gene Symbol:	IL12A

IL12A

CUI:	C0026769
Disease:	Multiple Sclerosis

Multiple Sclerosis

0.320

GeneticVariation

BEFREE

It could be suggested that the genetic variation in IL-12 A/C (-1188) and IFN-gamma A/T (+874) cytokine genes could be risk factors for MS patients.

19543959

2009