Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.220 Biomarker MGD Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. 23160464

2013
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.220 GeneticVariation BEFREE These findings suggest a gender dimorphism in the PRF1 association with MS and point to the presence of a generalized defect in the expression of genes that code for proteins involved in cell killing in a subgroup of male patients with PPMS. 20921521

2010
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.220 GeneticVariation BEFREE Although A91V was the most frequent variation and displayed a trend of association with multiple sclerosis (MS) in the first population of patients and controls (frequency of the 91V allele: 0.076 vs 0.043, P=0.044), we used it as a marker to confirm PRF1 involvement in MS and assessed its frequency in a second population of 966 patients and 1520 controls. 18496551

2008
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.220 Biomarker MGD An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. 15069016

2004
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.220 Biomarker MGD Perforin-dependent neurologic injury in a viral model of multiple sclerosis. 9736651

1998