Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
CUI: C0033300
Disease: Progeria
Progeria 		0.030 PosttranslationalModification BEFREE These cells display HGPS-like defects in nuclear morphology, decreased H3K9me3 and HP1, and increased histone H2AX phosphorylation marks of the DNA damage loci. 31156709

2019
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
CUI: C0033300
Disease: Progeria
Progeria 		0.030 Biomarker BEFREE We found that nuclear import of ATM requires the Ran gradient, and disruption of the Ran gradient in HGPS causes a defect in generating nuclear γ-H2AX in response to ionizing radiation. 30565836

2019
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
CUI: C0033300
Disease: Progeria
Progeria 		0.030 Biomarker BEFREE We find that the intensities of gammaH2AX foci appear significantly weaker in the G0/G1 phase HGPS cells compared to control cells. 27907109

2016