Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0033300
Disease: Progeria
Progeria 		0.030 AlteredExpression BEFREE Here we report that p53 isoforms are expressed in primary fibroblasts derived from HGPS patients, are associated with their accelerated senescence and that their manipulation can restore the replication capacity of HGPS fibroblasts. 29429991

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0033300
Disease: Progeria
Progeria 		0.030 Biomarker BEFREE Together, these results establish that progerin interferes with the coordination of essential DNA replication factors, causing replication stress, and is the primary signal for p53 activation leading to premature senescence in HGPS. 28483909

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0033300
Disease: Progeria
Progeria 		0.030 AlteredExpression BEFREE We demonstrate that telomerase extends HGPS cellular lifespan by decreasing progerin-induced DNA-damage signaling and activation of p53 and Rb pathways that otherwise mediate the onset of premature senescence. 20605919

2010