Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0033300
Disease: Progeria
Progeria 		0.030 GeneticVariation BEFREE Here, by gene editing we created isogenic human embryonic stem cells (ESCs) with heterozygous (G608G/+) or homozygous (G608G/G608G) LMNA mutation and biallelic WRN knockout, for modeling HGPS and WS pathogenesis, respectively. 29476423

2018
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0033300
Disease: Progeria
Progeria 		0.030 GeneticVariation BEFREE The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. 22797812

2012
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0033300
Disease: Progeria
Progeria 		0.030 Biomarker BEFREE We considered cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) with an altered nucleoskeletal protein; a mouse model of XFE progeroid syndrome caused by a deficiency of ERCC1-XPF DNA repair nuclease; and patients with Werner syndrome (WS) lacking a functional WRN exonuclease and helicase protein. 22127259

2012