Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 Biomarker BEFREE This is consistent with previous reports suggesting an association between moderate alpha 1-AT deficiency and psoriasis. 3489666

1986
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 Biomarker BEFREE Since MZ heterozygotes are almost always, and MS phenotypes sometimes, associated with decreased serum alpha 1-AT levels, and since Z and MZ phenotypes are associated with increased hepatic fibrosis or cirrhosis, these variants may be relevant to problems of spontaneous fibrosis or methotrexate-induced hepatotoxicity in psoriasis. alpha 1-AT deficiency may also contribute to guttate flares with infection and to increased O-2 . production by psoriatic sera-stimulated polymorphonuclear leukocytes (PMNs). 6333440

1984
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation BEFREE Association between psoriasis and the alpha 1-antitrypsin deficiency gene Z. 6155027

1980