Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.340 AlteredExpression BEFREE The mRNA expression of SIRT1 and SIRT3 was found to be significantly higher in diabetic patients with retinopathy compared to those without retinopathy. 30572719

2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.340 Biomarker BEFREE SIRT1 can control stem cell proliferation, block neuronal injury through limiting programmed cell death, drive vascular cell survival, and control clinical disorders that include dementia and retinopathy. 29523769

2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.340 AlteredExpression BEFREE Together these results indicate that although endogenous Sirt1 is important as a stress-induced protector in retinopathy, over-expression of Sirt1 or treatment with small molecule activators at the examined doses do not provide additional protection against retinopathy in mice. 24416337

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.340 Biomarker BEFREE SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling. 23395551

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.340 Biomarker CTD_human Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. 23217256

2012