Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE In addition, history of retinopathy was associated with the MTHFR C677T mutation in patients with DPN. 23901246

2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE Preventive therapies based on MTHFR polymorphism could delay the onset of retinopathy in type 2 diabetic patients. 18280442

2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE The MTHFR 677 TT was only related to earlier onset retinopathy in combination with MTRR 66GG. 18774994

2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease. 16274479

2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis. 15902512

2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.060 GeneticVariation BEFREE The frequencies of MTHFR TT homogeneous type, CT heterogeneous type and allele T (28.18%, 41.82%, 49.09%) were significantly higher in the type 2 diabetes mellitus with diabetic retinopathy group than those without retinopathy (18.37%, 29.59%, 33.16%) and those of controls (17.54%, 28.07%, 31.58%). 12667409

2003