|
SERPINE1
|
Retinal Diseases
|
0.070 |
GeneticVariation |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis.
|
23281898 |
2013 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
GeneticVariation |
BEFREE |
The association of altered plasminogen activator inhibitor (PAI)-1 levels and PAI-1 polymorphisms (4G/5G and -844G/A) with diabetic retinopathy (DR) was investigated in 856 type 2 diabetes (T2D) patients, of whom 383 presented with (DR group), and 473 presented without (DWR group), retinopathy.
|
19419896 |
2009 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
GeneticVariation |
BEFREE |
We conducted a case-control study on a total of 280 patients with Type 2 diabetes, comparing those without retinopathy or nephropathy (n = 92) and those with microangiopathies (n = 188), for the association of polymorphisms in four candidate genes, paraoxonase 1 (PON1), plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibalpha.
|
15270786 |
2004 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
Biomarker |
BEFREE |
The PAI-1 gene distribution and ACE gene distribution in patients with diabetic retinopathy (4G4G 31.4%, 4G5G 46.8%, 5G5G 21.8%; DD 26.6%, ID 50.8%, II 22.6%) were not significantly different from those of diabetic subjects without retinopathy (4G4G 31.3%, 4G5G 50%, 5G5G 18.7%; DD 31.3%, ID 40%, II 28.7%).
|
12660488 |
2003 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
GeneticVariation |
BEFREE |
Neither the PAI-1 nor the ApoE gene polymorphism contributes to the genetic susceptibility to diabetic nephropathy or retinopathy.
|
10809802 |
2000 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
AlteredExpression |
BEFREE |
In a logistic regression analysis controlled for age, sex, BMI, and duration of diabetes, any retinopathy was significantly associated with fasting plasma glucose concentrations (P < 0.05), 2-h postload glucose (P = 0.02), and HbA1c (P = 0.008), but not with PAI-1 activity (P = 0.48).
|
9250459 |
1997 |
|
SERPINE1
|
Retinal Diseases
|
0.070 |
AlteredExpression |
BEFREE |
To identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied.
|
7974340 |
1994 |