|
SERPINF1
|
Retinal Diseases
|
0.100 |
GeneticVariation |
BEFREE |
A small anti-angiogenic PEDF epitope (G-Y-D-L-Y-R-V) was identified, variants (adipic-Sar-Y-N-L-Y-R-V) mitigate CNV, with clinical potential in treating neovascular retinopathy.
|
31520600 |
2019 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
AlteredExpression |
BEFREE |
The treatment with DOR agonist prevented the upregulation of the early markers of retinopathy (glial fibrillary acidic protein, VEGF) and the downregulation of pigment epithelium-derived factor, occludin, claudin-1, and zonula occludens-1 tight junction expressions.
|
31529081 |
2019 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases.
|
29850214 |
2018 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.
|
28211523 |
2017 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
Here, we tested the efficacy of antiangiogenic gene transfer in an animal model that mimics the chronic progression of human DR. Adeno-associated viral (AAV) vectors of serotype 2 coding for antiangiogenic Pigment Epithelium Derived Factor (PEDF) were injected in the vitreous of a 1.5 month-old transgenic model of retinopathy that develops progressive neovascularization.
|
22911805 |
2012 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
AlteredExpression |
BEFREE |
The beneficial effects of SkQ1 on retinopathy connected with normalization of expression of VEGF and PEDF in the retina of OXYS rats and depended on age of the animals and the stage of retinopathy.
|
21750722 |
2011 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
AlteredExpression |
BEFREE |
Clinical signs of retinopathy OXYS rats manifest by the age 3 months against the background of significantly reduced expression level of VEGF and PEDF genes due to the decline of the amount of retinal pigment epithelium (RPE) cells and alteration of choroidal microcirculation.
|
21191149 |
2011 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
AlteredExpression |
BEFREE |
Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p<0.0001), or VEGF protein (p<0.0001).
|
21738387 |
2011 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
AlteredExpression |
BEFREE |
12-LOX and its product HETE are important regulators of retinal NV through modulation of VEGF and PEDF expression and could provide a new therapeutic target to prevent and treat ischemic retinopathy.
|
21228311 |
2011 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
Polymorphisms in protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) genes have been associated with diabetic nephropathy and retinopathy respectively.
|
20141354 |
2010 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
This PEDF effect was confirmed in the retina of rats with oxygen-induced retinopathy.
|
16901919 |
2006 |
|
SERPINF1
|
Retinal Diseases
|
0.100 |
Biomarker |
BEFREE |
These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.
|
10398599 |
1999 |