Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 AlteredExpression BEFREE Levels of vGAT and GABRA1, but not of GAT1, messenger RNAs (mRNAs) were lower in the PFC of the schizophrenia subjects. 24361861

2015
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker BEFREE Using double in situ hybridization in postmortem human prefrontal cortex, we found that the messenger RNA (mRNA) for the γ-aminobutyric acid (GABA) transporter GAT-1 was undetectable in 22-41% of PV neurons in layers 3-4 in schizophrenia. 25312391

2014
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker MGD These results identified a novel function of GAT1, and indicated that the elevated ambient GABA contributed critically to the pathogenesis of schizophrenia. 23922840

2013
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 AlteredExpression BEFREE Subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding (1) presynaptic regulators of GABA neurotransmission (67 kDa isoform of glutamic acid decarboxylase (GAD(67)) and GABA transporter 1), (2) neuropeptides (somatostatin (SST), neuropeptide Y (NPY) and cholecystokinin (CCK)) and (3) GABA(A) receptor subunits (alpha1, alpha4, beta3, gamma2 and delta). 17471287

2008
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker CTD_human Schizophrenia subjects showed significant decreases in mRNA levels of GAD(67), GAD(65), GAT-1, mGluR2, and neuronal nitric oxide synthase. 18923069

2008
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 AlteredExpression BEFREE GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neurons. 11156808

2001